Rat BRCA1 (Breast cancer type 1 susceptibility protein homolog) ELISA Kit
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Name
Rat BRCA1 (Breast cancer type 1 susceptibility protein homolog) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
ER1980
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | P14173 |
| Alias | BRCAI,BRCC1,BROVCA1,FANCS IRIS,PNCA4,PPP1R53,PSCP,RNF53,RING finger protein 53 |
| Background | Elisa kits for BRCA1 |
| Status | RUO |
Background
BRCA1 is a tumor suppressor protein that plays a central role in maintaining genomic stability through its involvement in DNA damage repair, cell cycle regulation, and transcriptional control. BRCA1 functions as part of the homologous recombination repair pathway, where it recognizes and repairs double-strand DNA breaks, ensuring genomic integrity during cell division. It forms complexes with other DNA repair proteins, including RAD51, BARD1, and BRCA2, to facilitate accurate repair processes. BRCA1 also regulates cell cycle checkpoints, particularly at the G2/M phase, to prevent the propagation of damaged DNA. It is widely expressed in proliferative tissues, including breast and ovarian tissue, where its loss or mutation is associated with increased susceptibility to breast, ovarian, and other cancers. Mutations in BRCA1 disrupt its DNA repair function, leading to chromosomal instability, accumulation of mutations, and tumorigenesis. BRCA1 also interacts with signaling pathways involved in apoptosis, transcriptional regulation, and immune response, further highlighting its multifaceted role in cellular homeostasis. Knockout studies reveal defective DNA repair, increased tumorigenesis, and impaired cell cycle control, underscoring BRCA1’s critical function in DNA repair, tumor suppression, and genomic stability.
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