Rat Bradykinin Receptor B2 (BDKRB2) Protein

Product specifications

Proteins and Peptides

Bradykinin Receptor B2 (BDKRB2)

E. coli

Activity: Not tested
Sequence Fragment: Please enquire.
Tag: N-terminal His tag

Rat

Unconjugated

Recombinant

> 90%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.

No

BDKRB2,B2BKR,B2BRA,BK-2 receptor.BK2R,bradykinin receptor, B2

Protein BDKRB2

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Descripción

Bradykinin Receptor B2 (BDKRB2) is a constitutively expressed GPCR that binds bradykinin, a peptide involved in the regulation of inflammatory responses, vasodilation, and pain signaling. BDKRB2 is widely expressed in endothelial cells, smooth muscle cells, and neurons, where it mediates vasodilation by stimulating the production of nitric oxide (NO) and prostacyclins. These effects help maintain blood flow and regulate vascular tone. In addition to its cardiovascular roles, BDKRB2 is involved in pain perception and edema formation during acute inflammation by increasing vascular permeability. In the kidneys, BDKRB2 contributes to sodium excretion and the regulation of blood pressure through the renin-angiotensin-aldosterone system (RAAS). Dysregulation of BDKRB2 has been implicated in hypertension, pulmonary edema, and inflammatory diseases, such as asthma and rheumatoid arthritis. BDKRB2 also plays roles in cancer biology, where its activation can promote tumor angiogenesis and invasion. Pharmacological modulation of BDKRB2 signaling, either through agonists or antagonists, has potential therapeutic applications for cardiovascular diseases, pain management, and inflammatory conditions.

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