Rat Bile Salt Export Pump (ABCB11) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ABCB11
proveedor
Abbexareference
abx514829Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Bile Salt Export Pump (ABCB11) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Bile Salt Export Pump (ABCB11) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
ABCB11, also known as the bile salt export pump (BSEP), is an essential transporter located on the canalicular membrane of hepatocytes. It is responsible for exporting bile salts from the liver into bile, a critical step in the digestion and absorption of dietary fats and the excretion of waste products. ABCB11 is ATP-dependent and plays a vital role in maintaining bile flow and preventing bile salt accumulation, which can damage liver cells. Mutations in the ABCB11 gene are associated with progressive familial intrahepatic cholestasis type 2 (PFIC2), a severe liver disorder characterized by impaired bile salt secretion and liver damage. Dysregulation or inhibition of ABCB11 is also implicated in drug-induced cholestasis and liver injury. Its essential function in bile production and liver health makes it a critical target for understanding and treating cholestatic diseases.
Características del producto
category
ELISA Kits
immunogen target
Bile Salt Export Pump (ABCB11)
reactivity
Rat
test range
78 pg/ml - 5000 pg/ml
sensitivity
< 33 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
ABCB11,ABC16,BRIC2,BSEP,PFIC-2,PFIC2,PGY4,SPGP
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ABCB11
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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