Rat Bcl2/Adenovirus E1B 19 kDa Interacting Protein 3 (BNIP3) CLIA Kit

Este producto es parte de BNIP3 - BCL2 interacting protein 3 (Like)
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845€ (96 tests)

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935106861
info@markelab.com
name
Rat Bcl2/Adenovirus E1B 19 kDa Interacting Protein 3 (BNIP3) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx190756
tested applications
CLIA

Description

Rat Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
CLIA Kits
Immunogen Target
Bcl2/Adenovirus E1B 19 kDa Interacting Protein 3 (BNIP3)
Reactivity
Rat
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
54.9 pg/ml - 40000 pg/ml
Sensitivity
< 22.7 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
CLIA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
NIP3,HABON,BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Background
CLIA Kits BNIP3
Status
RUO
Note
The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

BCL2 interacting protein 3 (BNIP3) is a pro-apoptotic member of the Bcl-2 family that plays a key role in regulating cell death, particularly in response to cellular stress BNIP3 functions by interacting with anti-apoptotic Bcl-2 family members, promoting mitochondrial outer membrane permeabilization, and facilitating the release of pro-apoptotic factors such as cytochrome c from the mitochondria This release activates the caspase cascade, triggering apoptosis BNIP3 is particularly involved in regulating hypoxia-induced cell death and autophagy, which are essential for cellular adaptation to low oxygen levels and nutrient stress Dysregulation of BNIP3 has been linked to various diseases, including cancer and neurodegenerative disorders, where altered expression of BNIP3 contributes to uncontrolled cell survival, tumor progression, and impaired cellular homeostasis BNIP3's role in mitochondrial function and its involvement in the hypoxic response make it an important factor in regulating cell death and adaptation to environmental stresses

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