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687.5€ (96 tests)
Rat ATP Binding Cassette Transporter C6 (ABCC6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Multidrug resistance-associated protein 6 concentrations in tissue homogenates, cell lysates and other biological fluids.
ATP Binding Cassette Subfamily C Member 6 (ABCC6) is primarily recognized for its involvement in regulating tissue calcification processes. Mutations in the ABCC6 gene are linked to pseudoxanthoma elasticum (PXE), a rare genetic disorder characterized by progressive mineralization of elastic fibers in the skin, eyes, and cardiovascular system. ABCC6 functions as an efflux transporter for ATP metabolites, such as inorganic pyrophosphate (PPi), a critical inhibitor of pathological calcification. Expressed predominantly in the liver and kidneys, ABCC6 indirectly regulates extracellular matrix homeostasis and mineralization processes in peripheral tissues. The transporter’s activity impacts not only PXE pathology but also vascular calcification seen in chronic kidney disease and atherosclerosis. ABCC6 remains a focal point of research for developing targeted therapies to modulate its function and mitigate disease progression, emphasizing its importance in both genetic and acquired calcification disorders.
ELISA Kits
ATP Binding Cassette Transporter C6 (ABCC6)
Rat
78 pg/ml - 5000 pg/ml
< 37 pg/ml
Sandwich
Quantitative
Colorimetric
Tissue homogenates,Cell lysates,Other biological fluids
96 tests
ABC34,ARA,EST349056,GACI2,MLP1,MOAT-E,Multidrug resistance-associated protein 6
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
ABCC6
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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