Rat Aryl Hydrocarbon Receptor (AhR) Protein

Este producto es parte de AHR - Aryl hydrocarbon receptor (repressor)
Rat Aryl Hydrocarbon Receptor (AhR) Protein

Pida mas información

935106861

info@markelab.com

Precio

273€ (10 µg)

Protein AHR

proveedor

Abbexa

reference

abx065465

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Aryl Hydrocarbon Receptor (AhR) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).


Background

AHR is a ligand-activated transcription factor involved in sensing and responding to environmental toxins, such as dioxins and polycyclic aromatic hydrocarbons (PAHs). Upon ligand binding, AHR translocates from the cytoplasm to the nucleus, where it forms a heterodimer with the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) and binds to DNA at xenobiotic response elements (XREs), regulating the expression of detoxification enzymes like CYP1A1 and CYP1B1. AHR is expressed in a variety of tissues, including the liver, skin, and immune system, and plays roles in xenobiotic metabolism, immune regulation, cell differentiation, and circadian rhythm modulation. Dysregulation of AHR activity is implicated in immune dysfunction, autoimmune diseases, and cancer, where it influences tumor progression and metastasis. AHR’s dual role in both normal homeostasis and pathological conditions makes it a target of interest in toxicology, immunology, and cancer research.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Aryl Hydrocarbon Receptor (AhR)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 32.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val311-Thr579 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

AHR


dry ice

No


availability

Shipped within 5-12 working days.


alias

RP85,bHLHe76


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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