Aryl Hydrocarbon Receptor (AHR) Antibody
312€ (60 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Aryl Hydrocarbon Receptor (AHR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx001244
Tested Applications
IHC
Description
AHR Antibody is a Rabbit Polyclonal antibody against AHR. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been largely regarded as a mediator of xenobiotic metabolism [PMID:18483242]. It plays a part role in physiologic activities, including attenuation of the acute phase response, cytokine signaling, T helper (TH)17 immune cell differentiation, modulation of NF-κB activity, and regulation of hormonal signaling [PMID:20423157,18540824]. It also mediates transcription factor sequestering away from a gene promoter or tethering of the AhR to a transcription factor on a promoter.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aryl Hydrocarbon Receptor (AHR) Immunogen: Recombinant fusion protein corresponding to human AHR |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35869 |
| Gene ID | 196 |
| NCBI Accession | NP_001612.1 |
| Alias | RP85,bHLHe76 |
| Background | Antibody anti-AHR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AHR is a ligand-activated transcription factor involved in sensing and responding to environmental toxins, such as dioxins and polycyclic aromatic hydrocarbons (PAHs). Upon ligand binding, AHR translocates from the cytoplasm to the nucleus, where it forms a heterodimer with the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) and binds to DNA at xenobiotic response elements (XREs), regulating the expression of detoxification enzymes like CYP1A1 and CYP1B1. AHR is expressed in a variety of tissues, including the liver, skin, and immune system, and plays roles in xenobiotic metabolism, immune regulation, cell differentiation, and circadian rhythm modulation. Dysregulation of AHR activity is implicated in immune dysfunction, autoimmune diseases, and cancer, where it influences tumor progression and metastasis. AHR’s dual role in both normal homeostasis and pathological conditions makes it a target of interest in toxicology, immunology, and cancer research.
Productos relacionados
Aryl Hydrocarbon Receptor (AHR) Antibody
AHR Antibody is a Rabbit Polyclonal antibody against AHR. The aryl hydrocarbon receptor (AhR) is a ligand-activated tran…
Ver producto
AhR (Phospho-Ser36) Antibody
Rabbit polyclonal antibody against AhR protein. Immunogen region is N-terminal. Specificity is as follows for the reacti…
Ver producto