Rat Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) ELISA Kit

Este producto es parte de AIFM - Apoptosis inducing factor mitochondria associated
Rat Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) ELISA Kit
643.5€ (96 tests)

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Name
Rat Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx155168
Tested Applications
ELISA

Description

Rat Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Apoptosis Inducing Factor (AIF) concentrations in serum, plasma, tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Apoptosis Inducing Factor (AIF)

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1)
Reactivity
Rat
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.07 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma, tissue homogenates and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
AIFM1,AIF,CMT2D,CMTX4,COWCK
Background
Elisa Kits for: AIFM1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

AIFM1 is a key mitochondrial protein that mediates caspase-independent apoptosis while also playing essential roles in mitochondrial energy metabolism. Located in the mitochondrial intermembrane space, AIFM1 translocates to the nucleus in response to apoptotic stimuli, where it induces chromatin condensation and large-scale DNA fragmentation. This translocation is triggered by mitochondrial outer membrane permeabilization during cellular stress. Beyond its apoptotic function, AIFM1 is crucial for maintaining mitochondrial respiratory chain integrity and supporting cellular energy homeostasis. Mutations in the AIFM1 gene have been implicated in neurodegenerative disorders and mitochondrial encephalomyopathies, highlighting its dual role in apoptosis and bioenergetics. Its regulation and activity are critical for cellular fate, as dysregulation can lead to either excessive apoptosis, contributing to degenerative diseases, or impaired apoptosis, facilitating cancer progression.

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