Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
357.5€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx038388
Tested Applications
ELISA, WB
Description
Rabbit Polyclonal against the AIFM1 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Immunogen: A peptide corresponding to the C-terminal region of human AIFM1 protein. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 67 kDa |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_001130846 |
| Alias | AIFM1,AIF,CMT2D,CMTX4,COWCK |
| Background | Antibody anti-AIFM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AIFM1 is a key mitochondrial protein that mediates caspase-independent apoptosis while also playing essential roles in mitochondrial energy metabolism. Located in the mitochondrial intermembrane space, AIFM1 translocates to the nucleus in response to apoptotic stimuli, where it induces chromatin condensation and large-scale DNA fragmentation. This translocation is triggered by mitochondrial outer membrane permeabilization during cellular stress. Beyond its apoptotic function, AIFM1 is crucial for maintaining mitochondrial respiratory chain integrity and supporting cellular energy homeostasis. Mutations in the AIFM1 gene have been implicated in neurodegenerative disorders and mitochondrial encephalomyopathies, highlighting its dual role in apoptosis and bioenergetics. Its regulation and activity are critical for cellular fate, as dysregulation can lead to either excessive apoptosis, contributing to degenerative diseases, or impaired apoptosis, facilitating cancer progression.
Productos relacionados
Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
AIFM1 Antibody is a Rabbit Polyclonal antibody against AIFM1. This gene encodes a flavoprotein essential for nuclear dis…
Ver producto
Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
AIFM1 is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermem…
Ver producto Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
Rabbit Polyclonal against the AIFM1 protein.…
Ver producto