Rat Apolipoprotein H (APOH) Protein

Product specifications

Proteins and Peptides

Apolipoprotein H (APOH)

E. coli

Rat

Unconjugated

Molecular Weight: Calculated MW: 35.0 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Gly20-Cys297
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

P26644

APOH, B2G1, B2GP1, BG, apolipoprotein H,β2-glycoprotein 1,beta-2 glycoprotein 1 ,Apolipoprotein H

Protein APOH

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Apolipoprotein H (APOH), also known as β2-glycoprotein I, is a multifunctional glycoprotein involved in lipid transport, coagulation, and immune regulation. APOH is primarily synthesized in the liver and circulates in the bloodstream, where it binds to phospholipids and lipoproteins, particularly VLDL and chylomicrons. APOH has a significant role in antiphospholipid syndrome (APS), an autoimmune disorder characterized by the presence of antiphospholipid antibodies that interfere with blood clotting. APOH interacts with anionic phospholipids and influences coagulation pathways, contributing to its function as a regulator of hemostasis and thrombosis. It also participates in lipid metabolism, facilitating the clearance of triglyceride-rich lipoproteins by binding to receptors on hepatocytes. Beyond its role in coagulation, APOH has immunological functions, such as modulating inflammatory responses and pathogen recognition, positioning it as a key player in the innate immune system. Elevated APOH levels have been associated with autoimmune diseases, cardiovascular disorders, and infectious diseases, underscoring its role in both homeostasis and disease progression. APOH’s diverse activities, including its interactions with lipids, immune factors, and coagulation pathways, make it an essential protein in physiology and a potential therapeutic target in autoimmune and thrombotic diseases.

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