Rat Apolipoprotein B-100 (APOB) Protein

Este producto es parte de APOB-Apolipoprotein B
Rat Apolipoprotein B-100 (APOB) Protein

Pida mas información

935106861

info@markelab.com

Precio

182€ (10 µg)

Protein APOB

proveedor

Abbexa

reference

abx065415

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Apolipoprotein B-100 (APOB) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).


Background

APOB is a major structural protein of low-density lipoproteins (LDL), very-low-density lipoproteins (VLDL), and chylomicrons, which are essential for lipid transport and metabolism in the body It exists in two primary isoforms: APOB-100, produced in the liver, and APOB-48, synthesized in the intestine APOB-100 is critical for the assembly and secretion of VLDL and LDL particles, facilitating the transport of cholesterol and triglycerides to peripheral tissues via binding to the LDL receptor (LDLR) Mutations or overexpression of APOB contribute to familial hypercholesterolemia and other dyslipidemias, leading to elevated LDL cholesterol levels and increased risk of atherosclerosis and cardiovascular diseases APOB-48, on the other hand, plays a key role in chylomicron formation and dietary fat absorption Genetic variations in the APOB gene have been linked to metabolic disorders, including obesity, diabetes, and fatty liver disease APOB levels serve as a marker of cardiovascular risk, with elevated concentrations indicating higher susceptibility to coronary artery disease Therapies targeting APOB, such as antisense oligonucleotides or LDL-lowering drugs like statins, have shown significant success in reducing cardiovascular events APOB remains a key focus in lipid biology due to its central role in lipid transport and cardiovascular health

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Apolipoprotein B-100 (APOB)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 23.8 kDa Observed MW: 24 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: H + Phe2747-Leu2913 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

APOB


dry ice

No


availability

Shipped within 5-7 working days.


alias

APOB, FLDB, LDLCQ4, apoB-100,apolipoprotein B, FCHL2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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