Apolipoprotein B (ApoB) Antibody
383.5€ (100 µl)
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935106861
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name
Apolipoprotein B (ApoB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012218
tested applications
ELISA, IF/ICC, FCM
Description
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypo beta lipoproteinemia, normotriglyceridemic hypo beta lipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Apolipoprotein B (ApoB) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC, FCM |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04114 |
| Gene ID | 338 |
| OMIM | 107730 |
| Alias | APOB, FLDB, LDLCQ4, apoB-100,apolipoprotein B, FCHL2 |
| Background | Antibody anti-APOB |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
APOB is a major structural protein of low-density lipoproteins (LDL), very-low-density lipoproteins (VLDL), and chylomicrons, which are essential for lipid transport and metabolism in the body It exists in two primary isoforms: APOB-100, produced in the liver, and APOB-48, synthesized in the intestine APOB-100 is critical for the assembly and secretion of VLDL and LDL particles, facilitating the transport of cholesterol and triglycerides to peripheral tissues via binding to the LDL receptor (LDLR) Mutations or overexpression of APOB contribute to familial hypercholesterolemia and other dyslipidemias, leading to elevated LDL cholesterol levels and increased risk of atherosclerosis and cardiovascular diseases APOB-48, on the other hand, plays a key role in chylomicron formation and dietary fat absorption Genetic variations in the APOB gene have been linked to metabolic disorders, including obesity, diabetes, and fatty liver disease APOB levels serve as a marker of cardiovascular risk, with elevated concentrations indicating higher susceptibility to coronary artery disease Therapies targeting APOB, such as antisense oligonucleotides or LDL-lowering drugs like statins, have shown significant success in reducing cardiovascular events APOB remains a key focus in lipid biology due to its central role in lipid transport and cardiovascular health
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