Rat Apelin Receptor (APLNR) Protein
1872€ (1 mg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Rat Apelin Receptor (APLNR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652537
tested applications
WB, SDS-PAGE
Description
Rat Apelin Receptor (APLNR) Protein is a Recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Apelin Receptor (APLNR) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | APLNR,angiotensin receptor-like 1,AGTRL1 ,APJ,APJR,angiotensin II receptor-like 1 ,B78,GPCR34 | G-protein coupled receptor APJ,APJR, HG11 |
| Background | Protein APLNR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The Apelin receptor (APLNR), also known as angiotensin receptor-like 1 (APJ), is a G-protein-coupled receptor (GPCR) that binds the apelin peptide ligand. APLNR is involved in numerous physiological processes, particularly in the cardiovascular system, where it regulates heart development, blood pressure, and vascular tone. Apelin signaling via APLNR enhances cardiac contractility and contributes to angiogenesis, promoting the formation of new blood vessels during tissue growth or injury. It plays a protective role in heart failure by reducing cardiac hypertrophy and improving ejection fraction. Additionally, the apelin/APLNR pathway is critical for fluid homeostasis and water balance, as it regulates vasopressin release in the hypothalamus. In the central nervous system, APLNR influences neuroprotection and neurodevelopment, modulating processes like neuronal survival and axon growth. The receptor is also significant in metabolic regulation, as it improves insulin sensitivity and glucose uptake, highlighting its relevance to obesity and type 2 diabetes. Dysregulation of APLNR signaling is associated with hypertension, pulmonary arterial hypertension, and pre-eclampsia, conditions related to abnormal vascular function. Furthermore, it has been implicated in cancer progression, where it enhances tumor angiogenesis and promotes tumor cell migration. APLNR's diverse roles in cardiovascular health, neurobiology, and metabolism make it a promising therapeutic target for cardiovascular disease, diabetes, and cancer.
