Rat Angiopoietin-Related Protein 2 (ANGPTL2) Protein

Este producto es parte de ANGPTL - Angiopoietin Like
Rat Angiopoietin-Related Protein 2 (ANGPTL2) Protein

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935106861

info@markelab.com

Precio

247€ (10 µg)

Protein ANGPTL2

proveedor

Abbexa

reference

abx065331

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Rat ANGPTL2 Protein is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).


Background

ANGPTL2 is a secreted glycoprotein that belongs to the angiopoietin-like (ANGPTL) protein family and plays critical roles in inflammation, angiogenesis, and tissue remodeling. ANGPTL2 promotes endothelial cell activation, migration, and vascular permeability, facilitating angiogenesis during wound healing and tissue repair. However, persistent overexpression of ANGPTL2 leads to chronic inflammation and tissue damage, contributing to the development of metabolic disorders, such as obesity and insulin resistance, as well as cardiovascular diseases. ANGPTL2 also enhances cancer progression by promoting tumor angiogenesis, metastasis, and epithelial-mesenchymal transition (EMT). Elevated ANGPTL2 levels are observed in various cancers, including breast, lung, and colorectal cancers, where its activity correlates with poor prognosis. It serves as a biomarker for inflammatory and tumor-associated conditions, linking inflammation to disease pathology. ANGPTL2’s dual role in tissue regeneration and chronic inflammation highlights its significance as a potential therapeutic target in cancer, cardiovascular diseases, and inflammatory disorders.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Angiopoietin-Related Protein 2 (ANGPTL2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 20.7 kDa Observed MW (SDS-PAGE): 20 kDa Concentration: Prior to lyophilization: 300 µg/ml Sequence Fragment: Leu141-Asp308 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ANGPTL2


dry ice

No


availability

Shipped within 5-12 working days.


alias

ARP2,HARP


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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