Rat Angiomotin-Like Protein 2 (AMOTL2) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Rat Angiomotin-Like Protein 2 (AMOTL2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501643
tested applications
ELISA
Description
Rat Angiomotin-Like Protein 2 (AMOTL2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Angiomotin-like protein 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Angiomotin-Like Protein 2 (AMOTL2) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | G3V735 |
| Alias | LCCP |
| Background | Elisa kits for AMOTL2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AMOTL2 is a member of the angiomotin (AMOT) protein family which regulates cellular processes such as angiogenesis, cell polarity, migration, and proliferation. AMOTL2 interacts with components of the Hippo signaling pathway specifically binding to YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) to regulate gene expression and maintain tissue homeostasis. By inhibiting YAP/TAZ nuclear translocation AMOTL2 acts as a tumor suppressor controlling cell proliferation and limiting excessive tissue growth. AMOTL2 plays a critical role in vascular development by stabilizing endothelial cell junctions and maintaining endothelial barrier integrity during angiogenesis. It interacts with cytoskeletal components such as actin filaments to mediate endothelial cell polarity and migration processes that are essential for blood vessel formation. AMOTL2 also regulates epithelial cell polarity during embryonic development influencing organogenesis and tissue architecture. In cancer biology AMOTL2 has dual roles depending on the cellular context. It can function as a tumor suppressor by restricting oncogenic YAP/TAZ signaling and inhibiting cell migration while in some cancers its dysregulation may promote tumor progression, metastasis, and angiogenesis. AMOTL2’s ability to control cell-cell junction stability and its involvement in actin cytoskeleton remodeling make it a key regulator of cellular structure and migration.
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