Rat Anaphase Promoting Complex Subunit 5 (ANAPC5) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ANAPC5
proveedor
Abbexareference
abx502125Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Anaphase Promoting Complex Subunit 5 (ANAPC5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Anaphase Promoting Complex Subunit 5 (ANAPC5) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Background
ANAPC5 is a structural subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) that contributes to the stability and assembly of the complex. It interacts with other subunits to form the platform necessary for substrate recognition and ubiquitination. ANAPC5 facilitates the recruitment of co-activators such as CDC20 and CDH1, which are required for targeting specific proteins for proteolysis during the cell cycle. By promoting the degradation of regulators like securin and cyclin B, ANAPC5 ensures proper chromosome segregation and mitotic exit. Loss or mutation of ANAPC5 impairs APC/C function, leading to cell cycle arrest, chromosomal instability, and an increased risk of cancer. ANAPC5’s role in the structural integrity of APC/C highlights its importance in maintaining genomic stability and normal cell division. Dysregulation of ANAPC5 is a hallmark of mitotic errors often observed in tumorigenesis.
Características del producto
category
ELISA Kits
immunogen target
Anaphase Promoting Complex Subunit 5 (ANAPC5)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
size 1
96 tests
alias
ANAPC5,APC5,Cyclosome subunit 5
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ANAPC5
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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proveedor
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