Rat Alad(Aminolevulinate Delta DehydRatase) ELISA Kit

Este producto es parte de ALAD - Delta-aminolevulinic acid dehydratase
Rat Alad(Aminolevulinate Delta DehydRatase) ELISA Kit

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935106861

info@markelab.com

Precio

Precio a consultar

Elisa Kits ALAD

proveedor

FineTest

reference

ER0632

Tested Applications

reactivity

rat

status

RUO

clonality


Background

Aminolevulinate Delta Dehydratase (ALAD) is a key enzyme in the heme biosynthesis pathway, catalyzing the condensation of two molecules of aminolevulinic acid (ALA) into porphobilinogen (PBG), a precursor to heme. ALAD is predominantly expressed in the liver and bone marrow, where heme production is critical for hemoglobin synthesis in red blood cells and for cytochrome function in metabolic processes. The enzyme requires zinc as a cofactor for its activity, and mutations or environmental inhibitors, such as lead, can impair ALAD function, leading to disorders such as porphyria or anemia. Lead poisoning inhibits ALAD by displacing zinc, resulting in the accumulation of ALA and associated neurotoxic effects. ALAD mutations can also cause ALAD porphyria, a rare genetic disorder marked by abdominal pain, neuropsychiatric symptoms, and photosensitivity. ALAD is a target of interest for understanding and mitigating lead toxicity and heme-related metabolic disorders.

Características del producto

category

ELISA Kits


reactivity

rat


test range

15.625-1000pg/ml


assay type

Sandwich ELISA, Double Antibody


assay data

Quantitative


detection method

Colorimetric


sample type

Serum,Plasma,Tissue homogenates,Other biological fluids


size 1

96T


alias

ALADH,Porphobilinogen synthase,ALA dehydratase


storage

2-8 °C for 6 months


or code

ALAD


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