Rat Akr7a2 (Aflatoxin B1 aldehyde reductase member 2) ELISA Kit
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name
Rat Akr7a2 (Aflatoxin B1 aldehyde reductase member 2) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
ER6066
tested applications
ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 78.125-5000pg/ml |
| Sensitivity | 46.875pg/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q8CG45 |
| Alias | AKR7A2,AFAR,AFAR1,AKR7 |
| Background | Elisa kits for Akr7a2 |
| Status | RUO |
AKR7A2 is a member of the aldo-keto reductase superfamily that plays a central role in detoxifying harmful aldehydes, including those generated from reactive oxygen species (ROS) and environmental toxins. It specifically reduces aflatoxin B1-dialdehyde, a highly toxic metabolite produced from aflatoxin exposure, into its less reactive alcohol form, protecting cells from aflatoxin-induced damage. AKR7A2 is highly expressed in the liver, kidneys, and gastrointestinal tract, where it safeguards against toxic metabolites arising from dietary toxins, such as aflatoxins, and endogenous lipid peroxidation products like 4-hydroxynonenal (4-HNE). It is also involved in detoxifying aldehydes produced during ethanol metabolism, linking it to alcohol-induced liver injury prevention. AKR7A2 has antioxidant properties that help maintain cellular redox balance under oxidative stress. Dysregulation of AKR7A2 can lead to increased susceptibility to aflatoxin-induced liver carcinogenesis, as inefficient detoxification exacerbates DNA damage and mutagenesis. Recent studies highlight its potential as a protective factor against environmental toxins and as a therapeutic target for liver disease prevention.
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