Rat Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3) ELISA Kit
715€ (96 tests)
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935106861
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name
Rat Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx555930
tested applications
ELISA
Description
Rat Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Aflatoxin B1 aldehyde reductase member 3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Aflatoxin B1 Aldehyde Reductase Member 3 (AKR7A3) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.78 ng/ml - 50 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 1-3 weeks. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P38918 |
| Alias | AKR7A3,AFAR2 |
| Background | Elisa kits for AKR7A3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKR7A3 shares significant structural and functional similarity with AKR7A2 and is involved in detoxifying aflatoxin B1-derived reactive aldehydes and other toxic carbonyl compounds. It functions as a critical enzyme in aldehyde metabolism, protecting cells from the damaging effects of reactive aldehydes produced during oxidative stress, lipid peroxidation, and xenobiotic metabolism. AKR7A3 is expressed in the liver and gastrointestinal tissues, where it contributes to the defense against dietary toxins, including aflatoxins and other environmental carcinogens. Its ability to detoxify lipid peroxidation products like 4-HNE and malondialdehyde highlights its role in preventing oxidative stress-related cellular damage and carcinogenesis. AKR7A3 also plays a role in maintaining liver homeostasis and mitigating toxin-induced liver injury. Dysregulation or reduced expression of AKR7A3 can increase susceptibility to liver cancer and chronic liver diseases by promoting the accumulation of reactive aldehydes and subsequent DNA damage. Emerging research focuses on its potential as a biomarker for toxin exposure and a target for improving antioxidant defenses in liver-related disorders.
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