Rat Adrenergic Receptor Beta 1 (ADRB1) Protein
1872€ (1 mg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Rat Adrenergic Receptor Beta 1 (ADRB1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652409
tested applications
WB, SDS-PAGE
Description
Rat Adrenergic Receptor Beta 1 (ADRb1) Protein is a Recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Adrenergic Receptor Beta 1 (ADRb1) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ADRB1,ADRB1R,Adrenergic receptor beta 1,RHR,B1AR,FNSS2,BETA1AR |
| Background | Protein ADRB1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The adrenergic receptor beta-1 (ADRB1) is a G-protein-coupled receptor that plays a critical role in cardiovascular physiology. Predominantly expressed in the heart, kidneys, and adipose tissues, ADRB1 mediates the effects of catecholamines such as epinephrine and norepinephrine. Upon activation, ADRB1 stimulates adenylate cyclase through Gs proteins, leading to increased cAMP production. This process enhances heart rate (positive chronotropy), contractility (positive inotropy), and conduction velocity (positive dromotropy), making it essential for the regulation of cardiac output. ADRB1 also influences renin secretion from the kidneys, impacting blood pressure regulation. Polymorphisms in the ADRB1 gene, such as Ser49Gly and Arg389Gly, have been linked to altered receptor activity, influencing individual responses to stress, exercise, and beta-blocker therapies. Dysregulation or overstimulation of ADRB1 is associated with conditions such as hypertension, heart failure, and arrhythmias, underscoring its significance as a therapeutic target in cardiovascular diseases.
Related Products
Human ADRB1 (Beta-1 adrenergic receptor) ELISA Kit
Ver Producto
Mouse Beta-1 Adrenergic Receptor (ADRB1) ELISA Kit
Mouse Beta-1 Adrenergic Receptor (ADRB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse ADRb1 concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of ADRb1
Ver Producto
Rat Beta-1 Adrenergic Receptor (ADRB1) ELISA Kit
Rat Beta-1 Adrenergic Receptor (ADRB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat ADRb1 concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of ADRb1
Ver Producto