Human ADRB1 (Beta-1 adrenergic receptor) ELISA Kit
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name
Human ADRB1 (Beta-1 adrenergic receptor) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH13954
tested applications
ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.313-20ng/ml |
| Sensitivity | 0.188ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | P08588 |
| Alias | ADRB1,ADRB1R,Adrenergic receptor beta 1,RHR,B1AR,FNSS2,BETA1AR |
| Background | Elisa kits for ADRB1 |
| Status | RUO |
The adrenergic receptor beta-1 (ADRB1) is a G-protein-coupled receptor that plays a critical role in cardiovascular physiology. Predominantly expressed in the heart, kidneys, and adipose tissues, ADRB1 mediates the effects of catecholamines such as epinephrine and norepinephrine. Upon activation, ADRB1 stimulates adenylate cyclase through Gs proteins, leading to increased cAMP production. This process enhances heart rate (positive chronotropy), contractility (positive inotropy), and conduction velocity (positive dromotropy), making it essential for the regulation of cardiac output. ADRB1 also influences renin secretion from the kidneys, impacting blood pressure regulation. Polymorphisms in the ADRB1 gene, such as Ser49Gly and Arg389Gly, have been linked to altered receptor activity, influencing individual responses to stress, exercise, and beta-blocker therapies. Dysregulation or overstimulation of ADRB1 is associated with conditions such as hypertension, heart failure, and arrhythmias, underscoring its significance as a therapeutic target in cardiovascular diseases.
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