Rat Activin A Receptor Type 1B (ACVR1B) Protein (Active)
1118€ (100 µg)
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Name
Rat Activin A Receptor Type 1B (ACVR1B) Protein (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx691050
Tested Applications
SDS-PAGE
Description
Rat ACVR1B Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat ACVR1B (Met1-Glu126) was expressed with the Fc region of human IgG1 at the C-terminus.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | ACVR1B |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Met1-Glu126 Tag: C-terminal Fc tag |
| Origin | Rat |
| Observed MW | 38.4 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_954700.1 |
| Alias | ACTR-IB,ALK-4,Serine/threonine-protein kinase receptor R2 (SKR2) |
| Background | Protein ACVR1B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg of the protein as determined by the LAL method. |
Background
ACVR1B, also known as ALK4, is a type I receptor primarily activated by activins, inhibins, and Nodal ligands. This receptor phosphorylates SMAD2/3 to propagate downstream signaling, which regulates cellular processes such as differentiation, proliferation, and embryonic patterning. ACVR1B is expressed in many tissues, particularly during early development. Mutations in ACVR1B have been associated with tumorigenesis and reproductive disorders due to its role in cell cycle regulation and tissue homeostasis.
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