Rat ABCC11 Protein

Este producto es parte de ABCC - ATP binding cassette subfamily C
Rat ABCC11 Protein
234€ (10 µg)

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Name
Rat ABCC11 Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx650881
Tested Applications
WB, SDS-PAGE

Description

Rat ABCC11 Protein is a recombinant Rat protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
ABCC11
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Ile1127-Leu1366
Tag: N-terminal His tag and GST tag
Origin
Rat
Conjugation
Unconjugated
Observed MW
Calculated MW: 56.7 kDa  Observed MW (SDS-PAGE): 56.7 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q6Y306
Alias
EWWD,MRP8,WW
Background
Protein ABCC11
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

ATP-binding cassette subfamily C member 11 (ABCC11), also known as multidrug resistance-associated protein 8 (MRP8), is an ATP-dependent transporter involved in the efflux of various organic anions, including bile acids, cyclic nucleotides, and conjugated steroid hormones. It is highly expressed in apocrine glands, liver, and breast tissue, playing a role in physiological processes like bile acid secretion and earwax type determination. ABCC11 has clinical significance in drug transport and metabolism, with variants linked to differences in drug sensitivity and cancer susceptibility. Mutations in ABCC11 are associated with traits like dry vs. wet earwax and body odor. It has two transmembrane and two nucleotide-binding domains typical of ABC transporters.

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