Rat 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase (ACMSD) ELISA Kit
715€ (96 tests)
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935106861
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name
Rat 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase (ACMSD) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx390969
tested applications
ELISA
Description
Rat 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase (ACMSD) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat ACMSD concentrations in serum, plasma and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase (ACMSD) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8R5M5 |
| Gene ID | 171385 |
| Alias | ACMSD |
| Background | Elisa kits for ACMSD |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
2-Amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD) is an enzyme involved in the tryptophan catabolic pathway, specifically in the kynurenine pathway. This pathway degrades tryptophan into several bioactive metabolites, some of which are precursors for NAD+ biosynthesis. ACMSD catalyzes the conversion of 2-amino-3-carboxymuconate-6-semialdehyde (ACMS) to 2-aminomuconate-6-semialdehyde (AMS), a step that diverts the pathway away from the production of quinolinic acid, a neuroactive compound. By regulating the flux of metabolites in the kynurenine pathway, ACMSD influences the balance between neurotoxic and neuroprotective metabolites. This enzyme is expressed in various tissues, including the brain, liver, and kidney, suggesting its importance in systemic metabolism and neuronal function. Dysregulation of ACMSD activity has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, as well as psychiatric disorders like schizophrenia. Research into the molecular mechanisms and regulation of ACMSD holds promise for understanding the pathogenesis of these disorders and developing therapeutic interventions targeting the kynurenine pathway. Further investigation is needed to explore the potential of ACMSD modulation as a strategy for neuroprotection and the treatment of neurological and psychiatric conditions.
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