Family main features
2-Amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD) is an enzyme involved in the tryptophan catabolic pathway, specifically in the kynurenine pathway. This pathway degrades tryptophan into several bioactive metabolites, some of which are precursors for NAD+ biosynthesis. ACMSD catalyzes the conversion of 2-amino-3-carboxymuconate-6-semialdehyde (ACMS) to 2-aminomuconate-6-semialdehyde (AMS), a step that diverts the pathway away from the production of quinolinic acid, a neuroactive compound. By regulating the flux of metabolites in the kynurenine pathway, ACMSD influences the balance between neurotoxic and neuroprotective metabolites. This enzyme is expressed in various tissues, including the brain, liver, and kidney, suggesting its importance in systemic metabolism and neuronal function. Dysregulation of ACMSD activity has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, as well as psychiatric disorders like schizophrenia. Research into the molecular mechanisms and regulation of ACMSD holds promise for understanding the pathogenesis of these disorders and developing therapeutic interventions targeting the kynurenine pathway. Further investigation is needed to explore the potential of ACMSD modulation as a strategy for neuroprotection and the treatment of neurological and psychiatric conditions.
The structural details of ACMSD include:
ACMSD is a member of the amidohydrolase superfamily and is classified based on its function in the kynurenine pathway. There are no known subtypes of ACMSD, but it shares structural and functional similarities with other enzymes in the amidohydrolase family.
ACMSD serves several critical roles in tryptophan metabolism:
ACMSD interacts with various molecules and pathways:
Alterations in ACMSD activity or expression can be linked to several pathological conditions:
2-Amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD) is a key enzyme in the kynurenine pathway of tryptophan catabolism. It regulates the production of NAD+ by catalyzing the decarboxylation of ACMS. ACMSD influences neuroprotection, immune responses, and overall tryptophan metabolism. Dysregulation of ACMSD activity is associated with various diseases, including neurodegenerative and inflammatory disorders, NAD+ deficiency, and psychiatric conditions. Understanding the structure, function, and clinical implications of ACMSD is vital for exploring therapeutic strategies targeting the kynurenine pathway and related metabolic processes.
2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase(ACMSD)
ACMSD
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con ACMSD - 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACMSD | abx384577 | Human 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase (ACMSD) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | 687.5 | 96 tests | Q8TDX5 | RUO | |
Abbexa | ACMSD | abx388570 | Mouse 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase (ACMSD) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q8R519 | RUO |
Abbexa | ACMSD | abx390969 | Rat 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase (ACMSD) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q8R5M5 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACMSD | abx334459 | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Antibody (FITC) | Human | Polyclonal | Rabbit | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) | FITC | 162.5 | 20 µg | Q8TDX5 | RUO | ||
Abbexa | ACMSD | abx334460 | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Antibody (Biotin) | Human | Polyclonal | Rabbit | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) | Biotin | ELISA | 162.5 | 20 µg | Q8TDX5 | RUO | |
Abbexa | ACMSD | abx038014 | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Antibody | Human | Polyclonal | Rabbit | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | ACMSD | abx334458 | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Antibody (HRP) | Human | Polyclonal | Rabbit | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) | HRP | ELISA | 162.5 | 20 µg | Q8TDX5 | RUO | |
Abbexa | ACMSD | abx213416 | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Antibody | Human | Polyclonal | Rabbit | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) | Unconjugated | ELISA, WB | 250 | 50 µl | Q8TDX5 | RUO | |
Abbexa | ACMSD | abx211507 | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Antibody | Human | Polyclonal | Rabbit | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q8TDX5 | RUO | |
Abbexa | ACMSD | abx338822 | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Antibody | Human | Polyclonal | Rabbit | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | Q8TDX5 | RUO |
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