Ras-related protein Rab-27A (RAB27A) Antibody
299€ (50 µl)
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Name
Ras-related protein Rab-27A (RAB27A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx402220
Tested Applications
ELISA, FCM
Description
Ras-related protein Rab-27A (RAB27A) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human RAB27A.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Ras-related protein Rab-27A (RAB27A) Immunogen: A synthesized peptide derived from human RAB27A |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | FCM: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, FCM |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51159 |
| Gene ID | 5873 |
| OMIM | 603868 |
| Alias | GS2,RAM,RAB27,HsT18676,GTP-binding protein Ram,Ras-related protein Rab-27A |
| Background | Antibody anti-RAB27A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAB27A, member RAS oncogene family (RAB27A) is a key regulator of vesicular trafficking, particularly in the movement of vesicles to the plasma membrane It is involved in the transport of lysosome-related organelles and granules, which play a role in processes such as immune response, secretion, and synaptic vesicle recycling RAB27A is crucial for the proper functioning of cytotoxic T lymphocytes, as it helps in the delivery of cytotoxic granules to target cells during immune responses RAB27A also contributes to the regulation of melanosome trafficking in melanocytes, impacting pigmentation processes Additionally, it has been implicated in cellular functions related to exocytosis, where it regulates the release of various molecules from cells, including neurotransmitters and hormones Dysregulation of RAB27A is linked to diseases such as Griscelli syndrome, a condition characterized by pigmentation defects, immune dysfunction, and neurological impairments Moreover, RAB27A’s role in vesicular trafficking connects it to cancer, where alterations in its function can contribute to abnormal cellular signaling, migration, and metastasis, making it a potential therapeutic target for cancer treatments
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