Ras-Related Protein Rab-11A (RAB11A) Antibody
169€ (20 µg)
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Name
Ras-Related Protein Rab-11A (RAB11A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx109363
Tested Applications
ELISA, IHC
Description
Ras-related protein Rab-11A Antibody is a Rabbit Polyclonal antibody against Ras-related protein Rab-11A.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Ras-Related Protein Rab-11A (RAB11A) Immunogen: Recombinant human Ras-related protein Rab-11A protein (2-213AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P62491 |
| Gene ID | 8766 |
| NCBI Accession | NP_001193765.1, NM_001206836.1 |
| OMIM | 605570 |
| Alias | RAB11,YL8,Ras-related protein Rab-11A |
| Background | Antibody anti-RAB11A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAB11A, member RAS oncogene family (RAB11A) is a highly conserved small GTPase that is integral to regulating intracellular vesicle trafficking, particularly in the recycling of endosomal components and maintaining the integrity of the Golgi apparatus RAB11A is involved in several key processes, such as the recycling of internalized receptors back to the plasma membrane, which is essential for regulating cell surface protein levels and maintaining normal receptor function This function makes RAB11A crucial for cellular signaling, as it modulates the availability of signaling receptors on the cell surface, impacting processes like growth factor signaling, immune responses, and neurotransmitter receptor regulation Additionally, RAB11A contributes to the organization and function of the microtubule network, which is vital for cell division, polarity, and maintaining cellular structure It is also involved in the proper organization of the actin cytoskeleton, which is important for maintaining cell shape and facilitating cellular movements such as migration and adhesion RAB11A has been implicated in several diseases, including cancer, where dysregulated vesicular trafficking and altered receptor recycling contribute to tumor growth, metastasis, and resistance to therapy Additionally, RAB11A’s role in the immune response and inflammatory signaling pathways makes it an important regulator of immune function Disruption in RAB11A’s activity can have significant consequences for cellular homeostasis, making it a critical factor in both healthy cellular processes and disease pathogenesis
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