Ras Association Domain-Containing Protein 1 (RASSF1) Antibody
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Description
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ras Association Domain-Containing Protein 1 (RASSF1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NS23 |
| Background | Antibody anti-RASSF1 |
| Status | RUO |
Descripción
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Ras Association Domain-Containing Protein 1 (RASSF1) Antibody
RASSF1 Antibody is a Rabbit Polyclonal antibody against RASSF1. This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011].
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Ras Association Domain-Containing Protein 1 (RASSF1) Antibody
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Ver Producto
Ras Association Domain-Containing Protein 1 (RASSF1) Antibody
RASSF1 Antibody is a Rabbit Polyclonal antibody against RASSF1. This gene encodes a protein similar to the RAS effector proteinsLoss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this geneThe inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter regionThe encoded protein was found to interact with DNA repair protein XPAThe protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrestSeveral alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Ver Producto