RAR Related Orphan Receptor Beta (RORB) Antibody
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Description
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAR Related Orphan Receptor Beta (RORB) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92753 |
| Alias | RZRB,EIG15,NR1F2,RORbeta,ROR-BETA,RZR-BETA,Nuclear receptor ROR-beta,Nuclear receptor RZR-beta,Nuclear receptor subfamily 1 group F member 2 |
| Background | Antibody anti-RORB |
| Status | RUO |
Descripción
RAR related orphan receptor B (RORB) is another member of the ROR family of nuclear receptors, playing a critical role in regulating the development of the central nervous system and circadian rhythms RORB is particularly important for the development of the retina and the regulation of visual processing, where it modulates the expression of genes involved in retinal cell differentiation and function It also participates in regulating the transcription of genes related to metabolism and cell growth, affecting cellular differentiation in multiple tissues RORB is involved in the regulation of sleep-wake cycles by modulating the circadian clock and influencing the expression of key clock genes Disruption in RORB expression is linked to several neurological disorders, including sleep disturbances and retinal degeneration, and may contribute to diseases like bipolar disorder and schizophrenia Its role in neurodevelopment and circadian regulation makes RORB a target for therapies aimed at treating neurological diseases and circadian rhythm disorders
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The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation.
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