RAR Related Orphan Receptor Beta (RORB) Antibody
292.5€ (80 µl)
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Name
RAR Related Orphan Receptor Beta (RORB) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx027769
Tested Applications
ELISA, WB, IHC
Description
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: RAR Related Orphan Receptor Beta (RORB) Immunogen: KLH-conjugated synthetic peptide between 329-358 amino acids from the C-terminal region of human RORB. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 53.2 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92753 |
| Alias | RZRB,EIG15,NR1F2,RORbeta,ROR-BETA,RZR-BETA,Nuclear receptor ROR-beta,Nuclear receptor RZR-beta,Nuclear receptor subfamily 1 group F member 2 |
| Background | Antibody anti-RORB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAR related orphan receptor B (RORB) is another member of the ROR family of nuclear receptors, playing a critical role in regulating the development of the central nervous system and circadian rhythms RORB is particularly important for the development of the retina and the regulation of visual processing, where it modulates the expression of genes involved in retinal cell differentiation and function It also participates in regulating the transcription of genes related to metabolism and cell growth, affecting cellular differentiation in multiple tissues RORB is involved in the regulation of sleep-wake cycles by modulating the circadian clock and influencing the expression of key clock genes Disruption in RORB expression is linked to several neurological disorders, including sleep disturbances and retinal degeneration, and may contribute to diseases like bipolar disorder and schizophrenia Its role in neurodevelopment and circadian regulation makes RORB a target for therapies aimed at treating neurological diseases and circadian rhythm disorders
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