RAR Related Orphan Receptor Alpha (RORA) Antibody (HRP)

Background

RAR related orphan receptor A (RORA) is a nuclear receptor that is involved in regulating circadian rhythms, neurodevelopment, and immune system function RORA is activated by retinoic acid, but unlike classic retinoic acid receptors, it is considered an "orphan" receptor due to its lack of well-characterized endogenous ligands RORA plays a crucial role in maintaining the body’s internal clock, influencing sleep-wake cycles and regulating the expression of genes involved in metabolic processes It is also involved in brain function, particularly in the regulation of cerebellar development and the formation of neural circuits Additionally, RORA influences immune system function, where it helps modulate inflammatory responses and autoimmunity Dysregulation of RORA has been associated with various diseases, including neurodegenerative diseases, autoimmune disorders, and psychiatric conditions like autism spectrum disorder and depression