RAR Related Orphan Receptor Alpha (RORA) Antibody
292.5€ (80 µl)
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Name
RAR Related Orphan Receptor Alpha (RORA) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx025951
Tested Applications
ELISA, WB, IF/ICC, FCM
Description
RORA is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: RAR Related Orphan Receptor Alpha (RORA) Immunogen: KLH-conjugated synthetic peptide between 193-222 amino acids from human RORA. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500, IF/ICC: 1/10 - 1/50, FCM: 1/25. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 59 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35398 |
| Alias | ROR1,ROR2,ROR3,RZRA,NR1F1,RORa1,IDDECA,RORalpha,RZR-ALPHA,Nuclear receptor ROR-alpha,Nuclear receptor subfamily 1 group F member 1,Retinoid-related orphan receptor-alpha |
| Background | Antibody anti-RORA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAR related orphan receptor A (RORA) is a nuclear receptor that is involved in regulating circadian rhythms, neurodevelopment, and immune system function RORA is activated by retinoic acid, but unlike classic retinoic acid receptors, it is considered an "orphan" receptor due to its lack of well-characterized endogenous ligands RORA plays a crucial role in maintaining the body’s internal clock, influencing sleep-wake cycles and regulating the expression of genes involved in metabolic processes It is also involved in brain function, particularly in the regulation of cerebellar development and the formation of neural circuits Additionally, RORA influences immune system function, where it helps modulate inflammatory responses and autoimmunity Dysregulation of RORA has been associated with various diseases, including neurodegenerative diseases, autoimmune disorders, and psychiatric conditions like autism spectrum disorder and depression
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