Rac-Gamma Serine/Threonine-Protein Kinase (AKT3) Antibody
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Description
Rac-Gamma Serine/Threonine-Protein Kinase (AKT3) Antibody is a monoclonal Nanobody expressed in CHO cells for the detection of Human AKT3.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Rac-Gamma Serine/Threonine-Protein Kinase (AKT3) |
| Host | CHO cells |
| Reactivity | Human |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | VHH-8His-Cys-tag |
| Clone ID | S778 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A/G affinity chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C or -80 °C for long-term storage. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y243 |
| Gene ID | 10000 |
| NCBI Accession | NP_001193658.1 |
| Alias | AKT3,PKBG,RAC-PK-gamma,STK-2 |
| Background | Antibody anti-AKT3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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AKT3 antibody
AKT3 is one of 3 closely related serine/threonine-protein kinases(AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
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