RAC-Gamma Serine/Threonine-Protein Kinase (AKT3) Antibody
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Description
RAC-Gamma Serine/Threonine-Protein Kinase (AKT3) Antibody is a Rabbit polyclonal antibody for the detection of Human RAC-Gamma Serine/Threonine-Protein Kinase (AKT3).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAC-Gamma Serine/Threonine-Protein Kinase (AKT3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y243 |
| Gene ID | 10000 |
| NCBI Accession | NP_001193658.1 |
| Alias | AKT3,PKBG,RAC-PK-gamma,STK-2 |
| Background | Antibody anti-AKT3 |
| Status | RUO |
Descripción
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AKT3 is one of 3 closely related serine/threonine-protein kinases(AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
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