RAC-Beta Serine/threonine-Protein Kinase (AKT2) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
RAC-Beta Serine/threonine-Protein Kinase (AKT2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037427
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the AKT2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAC-Beta Serine/threonine-Protein Kinase (AKT2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_001626 |
| Alias | AKT2,PKB beta,Protein kinase Akt ,Protein kinase B beta |
| Background | Antibody anti-AKT2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
AKT2, also known as RAC-beta serine/threonine-protein kinase, is one of the three isoforms of the AKT (Protein Kinase B) family of serine/threonine kinases. Like other AKT isoforms, AKT2 plays a crucial role in various cellular processes, including metabolism, cell survival, proliferation, and growth. AKT2 is a downstream effector of the PI3K (phosphoinositide 3-kinase) signaling pathway. Activation of AKT2 occurs through phosphorylation at key residues, including threonine 309 (Thr309) and serine 474 (Ser474). Once activated, AKT2 phosphorylates a wide range of substrates involved in diverse cellular functions. AKT2 regulates glucose uptake by promoting the translocation of glucose transporter type 4 (GLUT4) to the cell membrane, thereby facilitating glucose uptake into cells, particularly in insulin-responsive tissues like muscle and adipose tissue. Dysregulation of AKT2 signaling has been implicated in insulin resistance and type 2 diabetes. AKT2 is also involved in other cellular processes such as cell proliferation, survival, and migration. Dysregulation of AKT2 signaling has been implicated in various diseases, including cancer, metabolic disorders, and cardiovascular diseases.
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