RAC-Beta Serine/threonine-Protein Kinase (AKT2) Antibody

Este producto es parte de AKT2 - RAC-beta serine/threonine-protein kinase 2
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383.5€ (100 µl)

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935106861
info@markelab.com
name
RAC-Beta Serine/threonine-Protein Kinase (AKT2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx010368
tested applications
ELISA, WB, IHC, IF/ICC

Description

Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2), with 481-amino acid protein (about 53kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt3. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Among the members of AKT family, Akt2 is associated with the development of human cancers. Akt2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. Further, Akt2 plays a specific role in muscle differentiation.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
RAC-Beta Serine/threonine-Protein Kinase (AKT2)
Host
Mouse
Reactivity
Human, Rat, Monkey
Recommended Dilution
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG2b
Purification
Unpurified ascites.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC
Buffer
Ascitic fluid containing 0.03% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P31751
Gene ID
208
Alias
AKT2,PKB beta,Protein kinase Akt ,Protein kinase B beta
Background
Antibody anti-AKT2
Status
RUO
Note
Concentration: Not determined. -

Descripción

AKT2, also known as RAC-beta serine/threonine-protein kinase, is one of the three isoforms of the AKT (Protein Kinase B) family of serine/threonine kinases. Like other AKT isoforms, AKT2 plays a crucial role in various cellular processes, including metabolism, cell survival, proliferation, and growth. AKT2 is a downstream effector of the PI3K (phosphoinositide 3-kinase) signaling pathway. Activation of AKT2 occurs through phosphorylation at key residues, including threonine 309 (Thr309) and serine 474 (Ser474). Once activated, AKT2 phosphorylates a wide range of substrates involved in diverse cellular functions. AKT2 regulates glucose uptake by promoting the translocation of glucose transporter type 4 (GLUT4) to the cell membrane, thereby facilitating glucose uptake into cells, particularly in insulin-responsive tissues like muscle and adipose tissue. Dysregulation of AKT2 signaling has been implicated in insulin resistance and type 2 diabetes. AKT2 is also involved in other cellular processes such as cell proliferation, survival, and migration. Dysregulation of AKT2 signaling has been implicated in various diseases, including cancer, metabolic disorders, and cardiovascular diseases.

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