RAC-Beta Serine/threonine-Protein Kinase (AKT2) Antibody

Este producto es parte de AKT2 - RAC-beta serine/threonine-protein kinase 2
Product Graph
195€ (20 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
RAC-Beta Serine/threonine-Protein Kinase (AKT2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx000688
tested applications
ELISA, WB, IF/ICC

Description

AKT2 Antibody is a Rabbit Polyclonal antibody against AKT2. This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
RAC-Beta Serine/threonine-Protein Kinase (AKT2)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
20 µl
Size 2
100 µl
Size 3
2 × 100 µl
Form
Liquid
Tested Applications
ELISA, WB, IF/ICC
Buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P31751
Gene ID
208
NCBI Accession
NP_001617.1
Alias
AKT2,PKB beta,Protein kinase Akt ,Protein kinase B beta
Background
Antibody anti-AKT2
Status
RUO
Note
Concentration: > 0.2 mg/ml -

Descripción

AKT2, also known as RAC-beta serine/threonine-protein kinase, is one of the three isoforms of the AKT (Protein Kinase B) family of serine/threonine kinases. Like other AKT isoforms, AKT2 plays a crucial role in various cellular processes, including metabolism, cell survival, proliferation, and growth. AKT2 is a downstream effector of the PI3K (phosphoinositide 3-kinase) signaling pathway. Activation of AKT2 occurs through phosphorylation at key residues, including threonine 309 (Thr309) and serine 474 (Ser474). Once activated, AKT2 phosphorylates a wide range of substrates involved in diverse cellular functions. AKT2 regulates glucose uptake by promoting the translocation of glucose transporter type 4 (GLUT4) to the cell membrane, thereby facilitating glucose uptake into cells, particularly in insulin-responsive tissues like muscle and adipose tissue. Dysregulation of AKT2 signaling has been implicated in insulin resistance and type 2 diabetes. AKT2 is also involved in other cellular processes such as cell proliferation, survival, and migration. Dysregulation of AKT2 signaling has been implicated in various diseases, including cancer, metabolic disorders, and cardiovascular diseases.

Related Products

EH15498

Human AKT2 (RAC-beta serine/threonine-protein kinase) ELISA Kit

Ver Producto
FNab00272

AKT2 antibody

AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis and their activation has been observed in a wide variety of cancers. AKT2 is mainly involved in cancer cell survival, apoptosis inhibition, migration and invasion(PMID:21979951). The full length protein has four glycosylation sites.

Ver Producto
P0509

Recombinant Human AKT2

Ver Producto