935106861
info@markelab.com
Precio
812.5€ (96 tests)
Rabbit Toll Like Receptor 9 (TLR9) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Rabbit Toll Like Receptor 9 (TLR9) CLIA Kit es un kit CLIA de tipo sandwich para usar con homogenizados de tejidos, lisados celulares y otros fluidos biológicos.
Toll-like receptor 9 (TLR9) is an integral component of the immune system and a member of the Toll-like receptor (TLR) family, primarily involved in the recognition of pathogen-associated molecular patterns (PAMPs) within microbial DNA. TLR9 is uniquely specialized to detect unmethylated CpG motifs in DNA, which are frequently found in bacterial and viral genomes but rare in vertebrate DNA due to methylation. This distinction allows TLR9 to effectively recognize pathogenic DNA and initiate immune responses against infections. By detecting microbial DNA, TLR9 plays a pivotal role in the innate immune response and contributes to the activation of adaptive immunity. TLR9 is expressed in plasmacytoid dendritic cells (pDCs), B cells, and monocytes/macrophages, with its expression localized to the endosomes of these cells. This intracellular positioning is essential for its function, as it enables the receptor to sample nucleic acids from pathogens engulfed in endosomal compartments. Upon recognizing CpG motifs, TLR9 initiates a signaling cascade that promotes cytokine production and type I interferon release, critical for mounting an immune defense against pathogens and influencing the maturation of dendritic cells and the activation of T and B cells.
CLIA Kits
Toll Like Receptor 9 (TLR9)
Rabbit
0.312 ng/ml - 20 ng/ml
< 0.119 ng/ml
Sandwich
Quantitative
Lyophilized
Chemiluminescent
Tissue homogenates, cell lysates and other biological fluids.
96 tests
5 × 96 tests
10 × 96 tests
Toll-like receptor 9,CD289
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
TLR9
No
El rango y la sensibilidad pueden variar. Le recomendamos contactar con nosotros a fin de obtener la última información sobre posibles actualizaciones, que no estén representadas en este catalogo. Si necesita un rango específico, contáctenos y trataremos de ayudarle. Consulte sobre posible información que pueda ayudarle a elegir la dilución apropiada para sus muestras. Los kits CLIA están optimizados para la detección de muestras nativas, las proteínas recombinantes, pueden resultar problemáticas a causa de diferencias en la secuencia o cambios en la estructura terciaria.
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