Rabbit Interleukin-10 (IL10) Protein
377€ (20 µg)
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935106861
info@markelab.com
name
Rabbit Interleukin-10 (IL10) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694292
tested applications
SDS-PAGE
Description
Interleukin-10 (IL10) protein is a recombinant Rabbit protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin-10 (IL10) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Ser178 Tag: C-terminal His tag |
| Origin | Rabbit |
| Observed MW | Calculated MW: 17.6 kDa Observed MW (SDS-PAGE): 17 kDa |
| Expression | Recombinant |
| Purity | >80% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Size 3 | 500 µg |
| Size 4 | 1 mg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q9TSJ4 |
| Alias | CSIF,GVHDS,IL-10,IL10A,TGIF,Cytokine synthesis inhibitory factor |
| Background | Protein IL10 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile H2O. Do not vortex. |
Descripción
IL10 is an anti-inflammatory cytokine produced by macrophages, T regulatory cells, and other immune cells to suppress excessive immune responses and maintain tissue homeostasis IL10 signaling occurs through the IL-10 receptor (IL10R) and activates the JAK/STAT3 pathway, inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL1β, and IL6 It plays a pivotal role in immune tolerance, limiting damage caused by chronic inflammation and infections Dysregulation of IL10 expression is associated with autoimmune diseases, such as Crohn's disease, multiple sclerosis, and psoriasis IL10 also exerts immunosuppressive effects in the tumor microenvironment, facilitating tumor progression and immune evasion due to its inhibitory influence on T cells and antigen-presenting cells IL10-based therapies are being explored for managing inflammatory diseases and promoting immune modulation in cancer and chronic infections
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