RAB8B, Member RAS Oncogene Family (RAB8B) Antibody

Background

RAB8B, member RAS oncogene family (RAB8B) is closely related to RAB8A and shares many functions in vesicular trafficking, cell polarization, and synaptic function RAB8B is involved in the trafficking of vesicles between the Golgi apparatus and the plasma membrane, contributing to the delivery of membrane proteins and receptors to the cell surface RAB8B also regulates the movement of vesicles in other processes such as ciliogenesis and neuronal development, where it helps organize cellular structures like cilia and dendritic spines It has been implicated in cellular signaling pathways that influence growth, survival, and migration, particularly in response to environmental stimuli Similar to RAB8A, disruptions in RAB8B have been associated with neurodegenerative diseases, where impaired vesicular transport leads to dysfunction in synaptic activity and cell signaling Additionally, RAB8B plays a role in cellular responses to stress, and its dysregulation is associated with cancer, where changes in vesicular trafficking contribute to tumor growth and metastasis