RAB8B, Member RAS Oncogene Family (RAB8B) Antibody
312€ (60 µl)
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Name
RAB8B, Member RAS Oncogene Family (RAB8B) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx002652
Tested Applications
WB
Description
RAB8B Antibody is a Rabbit Polyclonal antibody against RAB8B. RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: RAB8B, Member RAS Oncogene Family (RAB8B) Immunogen: Recombinant fusion protein corresponding to human RAB8B |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 23 kDa Observed MW: 23 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92930 |
| Gene ID | 51762 |
| NCBI Accession | NP_057614.1 |
| Alias | Ras-related protein Rab-8B |
| Background | Antibody anti-RAB8B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAB8B, member RAS oncogene family (RAB8B) is closely related to RAB8A and shares many functions in vesicular trafficking, cell polarization, and synaptic function RAB8B is involved in the trafficking of vesicles between the Golgi apparatus and the plasma membrane, contributing to the delivery of membrane proteins and receptors to the cell surface RAB8B also regulates the movement of vesicles in other processes such as ciliogenesis and neuronal development, where it helps organize cellular structures like cilia and dendritic spines It has been implicated in cellular signaling pathways that influence growth, survival, and migration, particularly in response to environmental stimuli Similar to RAB8A, disruptions in RAB8B have been associated with neurodegenerative diseases, where impaired vesicular transport leads to dysfunction in synaptic activity and cell signaling Additionally, RAB8B plays a role in cellular responses to stress, and its dysregulation is associated with cancer, where changes in vesicular trafficking contribute to tumor growth and metastasis
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