RAB5A, Member RAS Oncogene Family (RAB5A) Antibody
195€ (20 µl)
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Name
RAB5A, Member RAS Oncogene Family (RAB5A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx001094
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
RAB5A Antibody is a Rabbit Polyclonal antibody against RAB5A. RAB5A (RAB5A, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB5A include borna disease, and venezuelan equine encephalitis. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RAB20.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: RAB5A, Member RAS Oncogene Family (RAB5A) Immunogen: Recombinant protein corresponding to RAB5A. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 24 kDa Observed MW: 24 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P20339 |
| Gene ID | 5868 |
| NCBI Accession | NP_004153.2 |
| Alias | RAB5,Ras-related protein Rab-5A |
| Background | Antibody anti-RAB5A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAB5A, member RAS oncogene family (RAB5A) is another member of the RAB family of small GTPases, playing a crucial role in regulating early endosome dynamics and vesicular trafficking RAB5A is involved in the initiation of endocytosis, controlling the fusion of early endosomes and the processing of internalized material It is essential for receptor-mediated endocytosis, where it helps sort and direct cargo for degradation or recycling within the cell RAB5A also participates in the regulation of cell signaling, including receptor tyrosine kinase signaling, and is involved in maintaining cellular communication and response to external signals Dysregulation of RAB5A activity has been linked to a variety of disorders, including cancer, where aberrant endosomal trafficking can influence tumor progression and metastasis Additionally, RAB5A plays a role in immune responses and the trafficking of immune receptors, further highlighting its importance in both normal cellular processes and disease pathogenesis
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