RAB3A-specific Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
RAB3A-specific Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx237025
tested applications
ELISA, WB, IHC, IF/ICC
Description
RAB3A-specific Antibody is a Rabbit Polyclonal against RAB3A-specific.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB3A-specific |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/500, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P20336 |
| Gene ID | 5864 |
| OMIM | 179490 |
| Alias | Ras-related protein Rab-3A,RAS-associated protein RAB3A |
| Background | Antibody anti-RAB3A |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
RAB3A, member RAS oncogene family (RAB3A) is another small GTPase that is primarily involved in regulating vesicular trafficking, particularly in neurons and endocrine cells RAB3A plays a pivotal role in the regulated release of neurotransmitters and hormones through its involvement in synaptic vesicle recycling and exocytosis It is essential for the proper functioning of synapses, where it helps control the fusion of synaptic vesicles with the plasma membrane, allowing for neurotransmitter release and signal transmission between neurons In addition to its function in neurotransmission, RAB3A is also involved in insulin secretion in pancreatic beta cells Dysregulation of RAB3A is associated with neurological disorders, such as epilepsy and neurodegenerative diseases, as well as metabolic disorders like diabetes, where impaired vesicle trafficking and hormone release contribute to disease progression Understanding RAB3A’s role in cellular transport and neurotransmission is critical for developing therapeutic strategies for neurological and metabolic diseases
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