RAB3A, Member RAS Oncogene Family (RAB3A) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
RAB3A, Member RAS Oncogene Family (RAB3A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx028328
tested applications
ELISA, WB
Description
RAB3A is involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB3A, Member RAS Oncogene Family (RAB3A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P20336 |
| Alias | Ras-related protein Rab-3A,RAS-associated protein RAB3A |
| Background | Antibody anti-RAB3A |
| Status | RUO |
Descripción
RAB3A, member RAS oncogene family (RAB3A) is another small GTPase that is primarily involved in regulating vesicular trafficking, particularly in neurons and endocrine cells RAB3A plays a pivotal role in the regulated release of neurotransmitters and hormones through its involvement in synaptic vesicle recycling and exocytosis It is essential for the proper functioning of synapses, where it helps control the fusion of synaptic vesicles with the plasma membrane, allowing for neurotransmitter release and signal transmission between neurons In addition to its function in neurotransmission, RAB3A is also involved in insulin secretion in pancreatic beta cells Dysregulation of RAB3A is associated with neurological disorders, such as epilepsy and neurodegenerative diseases, as well as metabolic disorders like diabetes, where impaired vesicle trafficking and hormone release contribute to disease progression Understanding RAB3A’s role in cellular transport and neurotransmission is critical for developing therapeutic strategies for neurological and metabolic diseases
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