RAB39B, Member RAS Oncogene Family (RAB39B) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
RAB39B, Member RAS Oncogene Family (RAB39B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx029788
tested applications
ELISA, WB
Description
This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB39B, Member RAS Oncogene Family (RAB39B) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96DA2 |
| Alias | WSN,BGMR,WSMN,MRX72,XLID72,Ras-related protein Rab-39B |
| Background | Antibody anti-RAB39B |
| Status | RUO |
Descripción
RAB39B, member RAS oncogene family (RAB39B) is a member of the RAB GTPase family that plays a crucial role in intracellular vesicular trafficking. Specifically, RAB39B regulates the movement of vesicles between the Golgi apparatus and other cellular compartments. This protein is involved in maintaining cellular homeostasis by ensuring the proper sorting and recycling of proteins, lipids, and other essential cellular cargo. RAB39B has also been shown to be involved in the regulation of synaptic vesicle trafficking in neurons, influencing the release of neurotransmitters and the recycling of synaptic vesicles. Its function in the nervous system is essential for neuronal communication and synaptic plasticity. Dysregulation of RAB39B has been linked to neurodevelopmental disorders, particularly intellectual disabilities and autism spectrum disorders, as its malfunction can impair vesicular trafficking and neural communication, resulting in cognitive and behavioral deficits. Furthermore, RAB39B’s involvement in cellular signaling and membrane dynamics suggests that it may also contribute to other pathologies such as neurodegenerative diseases.
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