P2Y Purinoceptor 11 (P2RY11) Antibody
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Description
P2RY11 Antibody is a Rabbit Polyclonal against P2RY11.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | P2Y Purinoceptor 11 (P2RY11) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/5000, WB: 1/200 - 1/1000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96G91 |
| Gene ID | 5032 |
| Alias | P2RY11,purinergic receptor P2Y,G-protein coupled 11,P2Y purinoreceptor 11,P2Y1 |
| Background | Antibody anti-P2RY11 |
| Status | RUO |
Descripción
P2RY11 is a G protein-coupled receptor activated by extracellular ATP and adenosine diphosphate (ADP). Unlike other P2Y receptors, P2RY11 couples to both Gs and Gq proteins, allowing it to stimulate adenylate cyclase and phospholipase C (PLC), increasing cAMP and calcium levels, respectively. P2RY11 is widely expressed in immune cells, including leukocytes, as well as in the heart and central nervous system, where it modulates inflammation, immune responses, and energy metabolism. P2RY11 regulates chemotaxis, immune cell activation, and cytokine secretion, playing an essential role in inflammatory and immune-mediated diseases. It also contributes to cellular energy balance through its regulation of cAMP. Dysregulation of P2RY11 has been linked to autoimmune disorders, cardiac dysfunction, and inflammatory conditions. Targeting P2RY11 has potential therapeutic implications in immune modulation, cardiovascular diseases, and conditions associated with ATP-mediated inflammation.
Related Products
P2Y Purinoceptor 11 (P2RY11) Antibody
P2RY11 Antibody is a Rabbit Polyclonal antibody against P2RY11. The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.
Ver ProductoP2Y Purinoceptor 11 (P2RY11) Antibody
P2RY11 Antibody is a Rabbit Polyclonal antibody against P2RY11.
Ver ProductoP2Y Purinoceptor 11 (P2RY11) Antibody
P2RY11 Antibody is a Rabbit Polyclonal against P2RY11.
Ver Producto