P2Y Purinoceptor 1 (P2RY1) Antibody
292.5€ (200 µl)
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name
P2Y Purinoceptor 1 (P2RY1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433086
tested applications
P-ELISA
Description
P2RY1 Antibody is a Goat Polyclonal antibody against P2RY1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: P2Y Purinoceptor 1 (P2RY1) Immunogen: abx615349 - Internal region, 247-257 AA: C-KDLDNSPLRRK |
| Host | Goat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 5028 |
| NCBI Accession | NP_002554.1 |
| Alias | P2RY1,ATP receptor,P2 purinoceptor subtype Y1,P2Y purinoceptor 1,platelet ADP receptor ,Purinergic receptor P2Y1,P2Y ATP receptor 1,P2Y1 receptor,purinergic receptor P2Y,P2Y1, SARCC |
| Background | Antibody anti-P2RY1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
P2RY1 is a G protein-coupled receptor (GPCR) that binds extracellular nucleotides such as ADP, acting as a key player in platelet aggregation, neurotransmission, and vascular tone. It couples to Gq proteins, activating phospholipase C (PLC) and increasing intracellular calcium levels, which triggers platelet activation and aggregation in response to ADP. P2RY1 is widely expressed in platelets, the central nervous system, and endothelial cells, where it regulates hemostasis, blood clot formation, and vasodilation. In the CNS, P2RY1 modulates neuronal excitability and synaptic transmission. Dysregulation of P2RY1 signaling is associated with thrombosis, stroke, and neuroinflammatory conditions. P2RY1 antagonists are being developed as antithrombotic agents to prevent clot formation in cardiovascular diseases. Its critical role in platelet function, vascular regulation, and neuroprotection highlights P2RY1 as a therapeutic target for thrombotic disorders and neurological diseases.
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