PTK2 (pY397) Antibody
299€ (50 µl)
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935106861
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name
PTK2 (pY397) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx243046
tested applications
ELISA, WB
Description
PTK2 (pY397) Antibody is a Monoclonal Antibody against PTK2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PTK2 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 1-2 weeks. |
| Storage | Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q05397 |
| Alias | FAK,FADK,FAK1,FRNK,FADK 1,PPP1R71,p125FAK,pp125FAK,Focal adhesion kinase-related nonkinase,Protein phosphatase 1 regulatory subunit 71,Protein-tyrosine kinase 2 |
| Background | Antibody anti-PTK2 |
| Status | RUO |
Descripción
Protein Tyrosine Kinase 2 (PTK2), also known as FAK (Focal Adhesion Kinase), is a non-receptor tyrosine kinase that plays a critical role in cell adhesion, migration, and signal transduction. PTK2 is primarily located at focal adhesion sites and is activated in response to integrin signaling and growth factor receptors. Structurally, PTK2 consists of an N-terminal FERM domain for membrane association, a central kinase domain for catalytic activity, and a C-terminal focal adhesion targeting (FAT) domain that mediates protein-protein interactions. PTK2 is crucial in cytoskeletal organization, integrin-mediated signaling, and cell motility, particularly in processes such as embryogenesis, wound healing, and angiogenesis. PTK2 is upregulated in various cancers, including breast, colorectal, and glioblastoma, where it promotes cell proliferation, survival, and metastasis. Dysregulation of PTK2 signaling can contribute to chemoresistance and increased tumor progression, making it a potential therapeutic target. In non-cancer contexts, PTK2 is essential for immune cell function, particularly for T-cell activation and macrophage responses. Additionally, PTK2 is implicated in neurological processes, such as synaptic plasticity and neuron survival. Its diverse roles make PTK2 a key mediator of cellular communication and mechanotransduction.
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