Proteinase-Activated Receptor 4 (F2RL3) Antibody
364€ (100 µg)
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935106861
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name
Proteinase-Activated Receptor 4 (F2RL3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx232921
tested applications
ELISA, WB, IHC
Description
F2RL3 Antibody is a Rabbit Polyclonal against F2RL3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Proteinase-Activated Receptor 4 (F2RL3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96RI0 |
| Alias | F2RL3,coagulation factor II receptor-like 3,protease-activated receptor 4,thrombin receptor-like 3,thrombin receptor-like 3,F2R like thrombin/trypsin receptor 3,PAR4 |
| Background | Antibody anti-F2RL3 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Proteinase-Activated Receptor 4 (F2RL3), or PAR4, is activated by thrombin and other serine proteases, including trypsin. It is primarily expressed in platelets, endothelial cells, and various immune cells. F2RL3 plays a crucial role in platelet aggregation, clot formation, and wound healing. Upon activation, PAR4 signals through Gi proteins to modulate cellular responses such as platelet activation, granule release, and thrombus formation. PAR4 is a key mediator of thrombin-induced platelet responses and works in concert with other PARs (like PAR1 and PAR3) to regulate the coagulation cascade. Dysregulation of F2RL3 signaling has been associated with thrombotic disorders, such as deep vein thrombosis and stroke. PAR4 antagonists are being investigated for their potential to prevent thrombosis, especially in cardiovascular diseases where clot formation is a major contributor to disease progression. Additionally, F2RL3’s role in immune cell activation and inflammation suggests it could be a target for managing inflammatory diseases and autoimmune disorders, as well as regulating immune responses during infection.
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