Proteinase-Activated Receptor 1 (F2R) Antibody (Biotin)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Proteinase-Activated Receptor 1 (F2R) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx303790
Tested Applications
ELISA
Description
F2R Antibody (Biotin) is a Rabbit Polyclonal against F2R conjugated to Biotin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Proteinase-Activated Receptor 1 (F2R) Immunogen: Recombinant human Proteinase-activated receptor 1 protein (42-102AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25116 |
| Gene ID | 2149 |
| OMIM | 187930 |
| Alias | F2R,protease-activated receptor 1,coagulation factor II, thrombin receptor,CF2R,HTR,PAR-1,PAR1,TR |
| Background | Antibody anti-F2R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Proteinase-Activated Receptor 1 (F2R), or PAR1, is a G protein-coupled receptor activated by thrombin, a serine protease involved in coagulation and cellular signaling. PAR1 activation occurs through proteolytic cleavage of its N-terminal domain, exposing a tethered ligand that activates the receptor. PAR1 couples to Gq, Gi, and G12/13 proteins, triggering diverse signaling pathways, including phospholipase C (PLC), MAPK, and Rho-mediated pathways. PAR1 is widely expressed in endothelial cells, platelets, smooth muscle cells, and neurons, where it regulates thrombosis, inflammation, vascular permeability, and tissue repair. In platelets, PAR1 activation promotes aggregation and thrombus formation, while in endothelial cells, it modulates vascular integrity and inflammation. Dysregulation of PAR1 contributes to thrombotic disorders, cancer progression, and inflammatory diseases. PAR1 antagonists, such as vorapaxar, are clinically used to reduce thrombotic events in patients with cardiovascular disease. Targeting PAR1 offers therapeutic benefits in thrombosis, cancer, and inflammatory vascular disorders.
Productos relacionados
Proteinase-Activated Receptor 1 (F2R) Antibody
F2R Antibody is a Rabbit Polyclonal Antibody against F2R.…
Ver producto
Proteinase-Activated Receptor 1 (F2R) Antibody
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteoly…
Ver producto
Human Proteinase-Activated Receptor 1 (F2R) ELISA Kit
Human Proteinase-Activated Receptor 1 (F2R) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human…
Ver producto