Proteinase-Activated Receptor 1 (F2R) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
Proteinase-Activated Receptor 1 (F2R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430024
tested applications
P-ELISA, WB
Description
F2R Antibody is a Goat Polyclonal antibody against F2R.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Proteinase-Activated Receptor 1 (F2R) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/64000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 2149 |
| NCBI Accession | NP_001983.2 |
| Alias | F2R,protease-activated receptor 1,coagulation factor II, thrombin receptor,CF2R,HTR,PAR-1,PAR1,TR |
| Background | Antibody anti-F2R |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Proteinase-Activated Receptor 1 (F2R), or PAR1, is a G protein-coupled receptor activated by thrombin, a serine protease involved in coagulation and cellular signaling. PAR1 activation occurs through proteolytic cleavage of its N-terminal domain, exposing a tethered ligand that activates the receptor. PAR1 couples to Gq, Gi, and G12/13 proteins, triggering diverse signaling pathways, including phospholipase C (PLC), MAPK, and Rho-mediated pathways. PAR1 is widely expressed in endothelial cells, platelets, smooth muscle cells, and neurons, where it regulates thrombosis, inflammation, vascular permeability, and tissue repair. In platelets, PAR1 activation promotes aggregation and thrombus formation, while in endothelial cells, it modulates vascular integrity and inflammation. Dysregulation of PAR1 contributes to thrombotic disorders, cancer progression, and inflammatory diseases. PAR1 antagonists, such as vorapaxar, are clinically used to reduce thrombotic events in patients with cardiovascular disease. Targeting PAR1 offers therapeutic benefits in thrombosis, cancer, and inflammatory vascular disorders.
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